Endocrine Abstracts

CNB is increasingly being used as a diagnostic test for thyroid nodules with an inadequate (Bethesda 1) or indeterminate (Bethesda 3 and 4) FNAC results, which can account for up to 30% of the samples in some studies. CNB, using larger specimens and histological sections rather than cytological samples, allows better definition. We propose a simplified four-tiered classification of CNB specimens instead of the Bethesda system and evaluate its efficiency compared to definitive ...

Introduction: Minimally invasive surgery has become the standard surgical procedure in Primary Hyperparathyroidism (PHP). Targeted parathyroidectomy is associated with a shorter operative duration, a lower risk of complications and a greater patient satisfaction. This approach is dependent on precise localization of the abnormal gland. 99mTc-sestamibi scintigraphy and ultrasonography are acceptable imaging modalities to detect parathyroid adenoma prior to operation but discrep...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Introduction: Detransition is the act of stopping or reversing a gender medical, social or surgical transition. The study’s purpose was to describe our experience with a group of transsexual people in detransition phase.Material and methods: A cohort of 204 people with gender incongruence attending the Identity Gender Unit Hospital Clinico of Valladolid from January 2014 to December 2022 was studied. Seven of those participants detransitioned and we...

Objective: To describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BM) of differentiated thyroid carcinoma (DTC).Methods: Multicenter retrospective observational study. Patients diagnosed with DTC and BM between 1980-2021 were included. A Cox regression was performed to study prognostic factors for 5- and 10-year survival. Kaplan-Meier and log-rank tests were performed for survival analysis and compa...

Introduction: First treatment in Graves’ disease consists in the administration of antithyroid drugs. The most common side effect is a rash, which affects about 5% patients and clears up if the drug is stopped. The other drug may then be used. The intolerance to both drugs is very rare, but in this situation early radioactive iodine or surgery may be the answer.Case report: Woman of 61 years old who developed primary hyperthiroidism, with levels of ...

Aim: Description of the differences between patients diagnosed of essential (EH) vs. secondary (SH) hypertension in our Outpatient Hypertension Clinic.Methods: Review of the Clinical Records and of the relevant literature. Comparisons were made by non-paired t-test in continuous variables and Fisher’s exact test in discrete variables.Results: From 1994 to 2018, 49 patients < 20 years old were referred to our (mostly adult)...

Objectives: Examine the relationship between choroidal thickness (CT) and renal function tests.Methods: Cross-sectional study with 42 eyes of 21 ocular treatment-naïve diabetic patients. Demographic and ocular data were analyzed as well as the following renal function tests: microalbuminuria, microalbumin/creatinine ratio and glomerular filtration rate (CKD-EPI and MDRD-4). Choroidal thickness was measured by swept-source ocular coherence tomography...

: Hepatic steatosis is a common obesity-associated pathology characterized by the accumulation of fat within the liver, which can progress to liver fibrosis, cirrhosis and ultimately lead to hepatocellular carcinoma. Remarkably, obesity and cancer course with a profound dysregulation of the genetic expression patterns and, particularly, with the aberrant expression of splicing variants that could contribute to the aggressiveness and comorbidities of these pathologies. Since th...

Obesity, a disease that is growing at epidemic proportions worldwide, is caused by a combination of genetic and lifestyle factors. One of the most common pathologies associated with obesity is hepatic steatosis, an accumulation of fat within the liver that can progress to liver fibrosis, cirrhosis, and ultimately lead to hepatocellular carcinoma. There is emerging evidence that alternative mRNA splicing, the key mechanism providing transcript and protein diversity, is dysregul...